The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer

Table 2 Ascertainment criteria for probands of population-based families identified at three sites through local cancer registries from 1996 to 2000

Parameter	San Francisco, California^a	Ontario, Canada^b	Melbourne and Sydney, Australia
Geographic area	Greater San Francisco Bay Area	Province of Ontario	Metropolitan Areas of Melbourne and Sydney
Period of diagnosis	1995–1998	1996–1998	1996–1999
Sampling criteria for females	Age 18–34: include all	Age 18–35: include all	Age 18–39: include all
	Age 35–64: include all meeting high risk criteria^c	Age 36–54: include all meeting high risk criteria^d or Ashkenazi heritage; sample 25% of those not meeting high risk criteria	Age 40–49: 50% random sample
	Age 35–64: sample 2.5% of whites and 15% of minorities not meeting high risk criteria	Age 55–69: sample 35% of those meeting high risk criteria^d or Ashkenazi heritage; sample 8.75% (35% × 25%) of those not meeting high risk criteria	Age 50–59: 25% random sample
Sampling criteria for males	Age 20–79: include all	Age 20–79: include all	Not applicable

^aRecruitment in 2001–2005 is continued for minority families from San Francisco Bay area (namely Latino, African-American, Chinese, Japanese, and Filipino families) and Orange County, California (namely Latino, African-American, and Filipino families). ^bRecruitment in 2001–2005 is continued for minority families. ^cBilateral breast cancer with first diagnosis before age 50 years, previous diagnosis of ovarian or childhood cancer, one or more first-degree relatives with breast, ovarian or childhood cancer. ^dPrevious diagnosis of breast or ovarian cancer; at least one first- or two second-degree relative(s) with breast or ovarian cancer; at least one second- or third-degree relative with breast cancer diagnosed before age 36 years, ovarian cancer diagnosed before age 61 years, multiple breast cancer primaries, both breast and ovarian cancer, or male breast cancer; at least three first-degree relatives with any combination of breast, ovarian, colon, prostate, or pancreatic cancer or sarcoma, with at least one diagnosis before age 51 years.

ISSN: 1465-542X