From: Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study
 | With CYP1A2 results | No CYP1A2 results5 (n = 36) | |||
---|---|---|---|---|---|
 | Caucasian1 (n = 125) | East Asian2 (n = 4) | Jewish3 (n = 10) | Other4 (n = 7) |  |
Risk factors | Â | Â | Â | Â | Â |
   Age (years) | 44.8 (4.8) | 46.8 (4.5) | 45.4 (3.1) | 44.7 (5.1) | 45.1 (4.4) |
   Weight (kg) | 68.1 (16.6) | 54.8 (3.1) | 59.4 (10.7) | 64.9 (17.9) | 69.1 (13.3) |
   BMI (kg/m2) | 25.3 (6.1) | 23.2 (0.9) | 22.6 (3.5) | 25.9 (6.5) | 25.8 (5.1) |
   WHR | 0.75 (0.06) | 0.75 (0.04) | 0.73 (0.07) | 0.77 (0.05) | 0.74 (0.06) |
   Age at menarche (years) | 12.8 (1.5) | 11.5 (1.3) | 12.2 (0.6) | 13.7 (1.6) | 12.6 (1.5) |
   Age at first birth (years) | 27.8 (5.7) | 29.5 (0.7) | 29.5 (2.7) | 25.6 (9.7) | 29.0 (6.4) |
   Number of live births | 1.4 (1.2) | 1.0 (1.2) | 2.1 (1.3) | 1.6 (1.3) | 1.5 (1.2) |
   Mammographic density (%)6 | 27.4 (23.2) | 47.6 (17.0) | 40.2 (22.7) | 25.9 (20.0) | 28.4 (20.5) |
   CYP1A2 activity (CMR)7 | 6.3 (3.0) | 6.5 (1.0) | 5.0 (1.0) | 6.1 (3.5) | - |
Hormones | Â | Â | Â | Â | Â |
   Estradiol (pmol/l) | 326.2 (217.0) | 188.0 (127.6) | 241.6 (173.3) | 337.9 (188.4) | 295.9 (221.5) |
   Free estradiol (%) | 2.1 (0.7) | 1.7 (0.5) | 1.8 (0.7) | 2.3 (0.7) | 2.3 (0.5) |
   SHBG (nmol/l) | 57.3 (27.1) | 70.8 (17.2) | 69.1 (26.6) | 48.4 (24.6) | 48.3 (19.0) |
   IGF-1 (ng/ml) | 158.5 (35.6) | 154.5 (36.2) | 139.7 (36.6) | 144.4 (24.8) | 143.4 (34.0) |
   IGFBP-3 (mg/l) | 2.7 (0.5) | 2.6 (0.4) | 2.7 (0.6) | 2.7 (0.4) | 2.6 (0.5) |
   Insulin (pmol/l) | 74.0 (43.6) | 47.4 (20.2) | 53.8 (33.6) | 86.0 (40.8) | 77.0 (36.8) |
Nutritional variables | Â | Â | Â | Â | Â |
   Caffeine intake (mg/day) | 161.0 (100.8) | 138.8 (90.9) | 132.0 (109.1) | 212.9 (148.6) | 58.0 (58.8) |
   Total energy intake (kcal/day) | 1707.9 (467.1) | 1640.0 (624.9) | 1568.2 (346.4) | 1995.4 (877.1) | 1749.3 (485.2) |
Blood lipids | Â | Â | Â | Â | Â |
Total cholesterol (mmol/l) | 4.7 (0.9) | 4.8 (0.4) | 4.8 (0.8) | 5.1 (0.9) | 5.0 (1.0) |
Triglycerides (mmol/l) | 1.3 (0.9) | 1.1 (0.1) | 1.1 (0.5) | 1.0 (0.6) | 1.5 (1.1) |