Table 3 CYP1A2 activity and malondialdehyde levels

Premenopausal (n = 146)³

   Serum MDA (μmol/l)¹

0.15 (0.07)

4.59

0.03

1.37 (1.15–1.63)

1.52 (1.30–1.77)

1.50 (1.28–1.74)

1.62 (1.38–1.91)

0.06

   Serum MDA adjusted for antioxidants (μmol/l)²

0.14 (0.07)

4.23

0.04

1.33 (1.12–1.57)

1.39 (1.19–1.62)

1.47 (1.27–1.71)

1.53 (1.31–1.79)

0.05

   Total urinary MDA (μmol/day)¹

0.23 (0.11)

4.24

0.04

2.35 (1.81–3.06)

2.44 (1.92–3.09)

3.06 (2.44–3.84)

2.78 (2.18–3.53)

0.06

   Total urinary MDA adjusted for antioxidants (mol/day)

0.24 (0.11)

4.36

0.04

2.33 (1.78–3.05)

2.37 (1.81–3.09)

2.90 (2.29–3.68)

2.75 (2.14–3.54)

0.08

   dG-MDA (ρ mol/mg DNA)¹

-0.13 (0.15)

0.72

0.40

186.8 (126.5–275.9)

160.1 (112.5–227.6)

157.0 (111.6–220.8)

153.6 (106.9–220.6)

0.29

   dG-MDA adjusted for antioxidants (ρ mol/mg DNA)

-0.09 (0.16)

0.35

0.55

187.2 (126.0–278.1)

164.7 (115.0–235.7)

143.9 (101.7–203.6)

163.0 (113.0–235.2)

0.35

Postmenopausal (n = 149)⁴

   Serum MDA (μmol/l)¹

-0.00 (0.09)

0.00

0.99

1.73 (1.45–2.07)

1.63 (1.36–1.95)

1.55 (1.31–1.83)

1.72 (1.49–1.99)

0.86

   Serum MDA adjusted for antioxidants (μmol/l)

0.08 (0.09)

0.73

0.39

1.71 (1.42–2.04)

1.66 (1.38–1.99)

1.62 (1.35–1.94)

1.81 (1.55–2.1 0)

0.52

   Total urinary MDA (μmol/day)¹

-0.06 (0.11)

0.31

0.58

4.06 (3.24–5.09)

3.75 (2.97–4.72)

3.77 (3.05–4.65)

3.69 (3.62–3.76)

0.43

   Total urinary MDA adjusted for antioxidants (μmol/day)

-0.12 (0.11)

1.11

0.29

4.02 (3.20–5.04)

3.82 (3.03–4.80)

4.08 (3.25–5.11)

3.70 (3.06–4.47)

0.20

   dG-MDA (ρ mol/mg DNA)¹

0.16 (0.16)

0.93

0.34

141.2 (101.4–196.6)

135.1 (96.6–188.9)

133.9 (98.2–182.5)

156.8 (119.4–205.9)

0.57

   dG-MDA adjusted for antioxidants (ρ mol/mg DNA)

0.17 (0.17)

0.98

0.32

153.7 (109.3–216.2)

143.9 (101.9–203.2)

147.1 (105.2–205.6)

167.0 (125.4–222.3)

0.56