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Table 4 mRNA levels of seven selected genes in 97 estrogen receptor alpha-positive breast tumors

From: Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma

 

mRNA levels

Expression status

Gene

Mean ± SD

Median

Range

Underexpresseda

Normal

Overexpressedb

CYP2A6

344.0c ± 1540.6

0.9

0.001–9741.1

15 (15.5)d

58 (59.8)d

24 (24.7)d

CYP2B6

103.3 ± 172.7

37.0

0.03–1053.1

1 (1.0)

22 (22.7)

74 (76.3)

FMO5

5.2 ± 6.3

2.6

0.10–30.1

1 (1.0)

43 (44.3)

53 (54.7)

GSTM3

3.1 ± 3.5

2.0

0.07–21.2

2 (2.1)

60 (61.8)

35 (36.1)

SULT2B1

7.5 ± 10.5

4.5

0.17–84.4

0

61 (62.9)

36 (37.1)

NAT1

46.5 ± 55.4

21.5

1.1–295.6

0

20 (20.6)

77 (79.4)

ABCC11

37.1 ± 60.4

15.9

0.04–461.7

3 (3.1)

27 (27.8)

67 (69.1)

  1. a Less than mean values for the normal breast Ntarget minus two standard deviations (SDs) (or Ntarget value = 0.1 when the latter calculation gave a negative value). b Greater than mean values for the normal breast Ntarget plus five SDs. c The n-fold differences in target gene expression relative to the TATA box-binding protein (TBP) gene and the normal breast tissues. d Number of patients (percentage).
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Breast Cancer Research

ISSN: 1465-542X

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