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Table 3 mRNA levels of MKI67, ESR1/ERα and the 20 target genes expressed in breast tissues

From: Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma

  

Normal breast tissues, group I (n = 8)

ERα-negative breast tumors, group II (n = 5)

ERα-positive breast tumors, group III (n = 17)

Group III vs group I

Group III vs group II

Gene

Normal liver tissue

Mean ± SD

Range

Mean ± SD

Range

Mean ± SD

Range

P a

P a

CYP1B1

0.02

1.0b ± 0.3

0.5–1.3

11.2b ± 18.5

0.6–43.9

2.0b ± 2.8

0.3–11.8

NS

0.033

CYP2A6

9.8

1.0 ± 1.2

0.2–3.8

0.3 ± 0.1

0.1–0.4

737.9 ± 1931.2

0.01–7228.8

NS

0.048

CYP2B6

0.12

1.0 ± 0.8

0.1–2.3

0.2 ± 0.1

0.03–0.24

73.3 ± 87.7

0.8–249.8

0.0023

0.0090

CYP2D6

5.8

1.0 ± 0.6

0.3–1.7

3.4 ± 2.8

1.0–8.3

1.0 ± 0.6

0.3–2.3

NS

0.0054

CYP2E

0.97

1.0 ± 0.4

0.6–1.4

0.8 ± 0.5

0.2–1.4

1.5 ± 1.2

0.3–4.2

NS

NS

FMO1

4.7

1.0 ± 0.4

0.6–1.4

0.6 ± 0.5

0.2–1.3

0.6 ± 0.5

0.1–2.0

NS

NS

FMO5

28.5

1.0 ± 0.3

0.5–1.6

1.4 ± 2.1

0.2–5.1

3.4 ± 3.2

0.2–12.2

NS

0.042

NAT1

1.2

1.0 ± 0.3

0.5–1.5

0.5 ± 0.4

0.1–1.0

24.1 ± 29.0

1.2–105.2

0.0031

0.0009

COMT

0.47

1.0 ± 0.2

0.8–1.3

2.2 ± 1.5

0.3–4.3

0.9 ± 0.5

0.3–2.3

NS

NS

NQO1

0.009

1.0 ± 0.9

0.2–2.8

0.9 ± 0.9

0.1–2.0

1.4 ± 1.5

0.1–5.2

NS

NS

EPHX1

0.75

1.0 ± 0.9

0.2–2.1

0.3 ± 0.3

0.1–0.8

0.4 ± 0.3

0.1–1.0

NS

NS

SULT1A1

1.8

1.0 ± 0.7

0.3–1.6

0.6 ± 0.5

0.1–1.2

1.1 ± 0.9

0.4–3.3

NS

NS

SULT2B1

0.001

1.0 ± 1.0

0.0–2.9

1.7 ± 1.4

0.1–3.3

6.9 ± 6.9

0.4–24.0

0.0094

NS

GSTP1

0.54

1.0 ± 0.5

0.7–1.7

2.4 ± 4.0

0.2–9.4

0.9 ± 0.4

0.1–1.6

NS

NS

GSTM1

0.27

1.0 ± 1.2

0.0–2.6

0.05 ± 0.11

0.0–0.2

0.5 ± 1.1

0.0–4.3

NS

NS

GSTM3

0.23

1.0 ± 0.4

0.5–1.6

0.8 ± 1.3

0.1–3.0

2.7 ± 2.6

0.2–9.3

NS

0.011

GSTT1

0.35

1.0 ± 0.9

0.0–2.3

0.4 ± 0.3

0.1–0.7

0.6 ± 0.6

0.0–2.2

NS

NS

ABCB1

1.6

1.0 ± 1.2

0.4–2.8

0.3 ± 0.1

0.01–0.4

0.4 ± 0.4

0.1–1.3

NS

NS

ABCC1

0.16

1.0 ± 0.3

0.8–1.3

1.0 ± 0.7

0.3–2.2

0.9 ± 0.4

0.2–1.7

NS

NS

ABCC11

0.25

1.0 ± 0.9

0.4–3.3

31.2 ± 39.0

0.1–81.0

26.8 ± 36.8

0.1–108.3

0.039

NS

MKI67

70.3

1.0 ± 0.9

0.2–2.1

17.4 ± 6.6

10.0–26.6

13.0 ± 9.1

2.6–31.8

0.0023

NS

ESR1/ERα

0.002

1.0 ± 0.3

0.6–1.3

0.03 ± 0.02

0.01–0.05

29.6 ± 23.2

7.2–76.7

0.0023

0.0009

  1. ERα, estrogen receptor alpha; SD, standard deviation. a P value, Mann–Whitney test. NS, not significant. b Mean of mRNA levels as determined in Materials and methods.