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Table 3 mRNA levels of MKI67, ESR1/ERα and the 20 target genes expressed in breast tissues

From: Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma

   Normal breast tissues, group I (n = 8) ERα-negative breast tumors, group II (n = 5) ERα-positive breast tumors, group III (n = 17) Group III vs group I Group III vs group II
Gene Normal liver tissue Mean ± SD Range Mean ± SD Range Mean ± SD Range P a P a
CYP1B1 0.02 1.0b ± 0.3 0.5–1.3 11.2b ± 18.5 0.6–43.9 2.0b ± 2.8 0.3–11.8 NS 0.033
CYP2A6 9.8 1.0 ± 1.2 0.2–3.8 0.3 ± 0.1 0.1–0.4 737.9 ± 1931.2 0.01–7228.8 NS 0.048
CYP2B6 0.12 1.0 ± 0.8 0.1–2.3 0.2 ± 0.1 0.03–0.24 73.3 ± 87.7 0.8–249.8 0.0023 0.0090
CYP2D6 5.8 1.0 ± 0.6 0.3–1.7 3.4 ± 2.8 1.0–8.3 1.0 ± 0.6 0.3–2.3 NS 0.0054
CYP2E 0.97 1.0 ± 0.4 0.6–1.4 0.8 ± 0.5 0.2–1.4 1.5 ± 1.2 0.3–4.2 NS NS
FMO1 4.7 1.0 ± 0.4 0.6–1.4 0.6 ± 0.5 0.2–1.3 0.6 ± 0.5 0.1–2.0 NS NS
FMO5 28.5 1.0 ± 0.3 0.5–1.6 1.4 ± 2.1 0.2–5.1 3.4 ± 3.2 0.2–12.2 NS 0.042
NAT1 1.2 1.0 ± 0.3 0.5–1.5 0.5 ± 0.4 0.1–1.0 24.1 ± 29.0 1.2–105.2 0.0031 0.0009
COMT 0.47 1.0 ± 0.2 0.8–1.3 2.2 ± 1.5 0.3–4.3 0.9 ± 0.5 0.3–2.3 NS NS
NQO1 0.009 1.0 ± 0.9 0.2–2.8 0.9 ± 0.9 0.1–2.0 1.4 ± 1.5 0.1–5.2 NS NS
EPHX1 0.75 1.0 ± 0.9 0.2–2.1 0.3 ± 0.3 0.1–0.8 0.4 ± 0.3 0.1–1.0 NS NS
SULT1A1 1.8 1.0 ± 0.7 0.3–1.6 0.6 ± 0.5 0.1–1.2 1.1 ± 0.9 0.4–3.3 NS NS
SULT2B1 0.001 1.0 ± 1.0 0.0–2.9 1.7 ± 1.4 0.1–3.3 6.9 ± 6.9 0.4–24.0 0.0094 NS
GSTP1 0.54 1.0 ± 0.5 0.7–1.7 2.4 ± 4.0 0.2–9.4 0.9 ± 0.4 0.1–1.6 NS NS
GSTM1 0.27 1.0 ± 1.2 0.0–2.6 0.05 ± 0.11 0.0–0.2 0.5 ± 1.1 0.0–4.3 NS NS
GSTM3 0.23 1.0 ± 0.4 0.5–1.6 0.8 ± 1.3 0.1–3.0 2.7 ± 2.6 0.2–9.3 NS 0.011
GSTT1 0.35 1.0 ± 0.9 0.0–2.3 0.4 ± 0.3 0.1–0.7 0.6 ± 0.6 0.0–2.2 NS NS
ABCB1 1.6 1.0 ± 1.2 0.4–2.8 0.3 ± 0.1 0.01–0.4 0.4 ± 0.4 0.1–1.3 NS NS
ABCC1 0.16 1.0 ± 0.3 0.8–1.3 1.0 ± 0.7 0.3–2.2 0.9 ± 0.4 0.2–1.7 NS NS
ABCC11 0.25 1.0 ± 0.9 0.4–3.3 31.2 ± 39.0 0.1–81.0 26.8 ± 36.8 0.1–108.3 0.039 NS
MKI67 70.3 1.0 ± 0.9 0.2–2.1 17.4 ± 6.6 10.0–26.6 13.0 ± 9.1 2.6–31.8 0.0023 NS
ESR1/ERα 0.002 1.0 ± 0.3 0.6–1.3 0.03 ± 0.02 0.01–0.05 29.6 ± 23.2 7.2–76.7 0.0023 0.0009
  1. ERα, estrogen receptor alpha; SD, standard deviation. a P value, Mann–Whitney test. NS, not significant. b Mean of mRNA levels as determined in Materials and methods.