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Table 2 Target genes tested

From: Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma

Genea Genbank accession Number Chromosomal location Description
Phase I enzymes    
CYP1A1 NM_000499 15q24.1 Cytochrome P450, subfamily IA, polypeptide 1
CYP1A2 NM_000761 15q24.2 Cytochrome P450, subfamily IA, polypeptide 2
CYP1B1 NM_000104 2p21 Cytochrome P450, subfamily IB, polypeptide 1
CYP2A6 NM_000762 19q13.2 Cytochrome P450, subfamily IIA, polypeptide 6
CYP2B6 NM_000767 19q13.2 Cytochrome P450, subfamily IIB, polypeptide 6
CYP2C9 NM_000771 10q24.1 Cytochrome P450, subfamily IIC, polypeptide 9
CYP2D6 NM_000106 22q13.1 Cytochrome P450, subfamily IID, polypeptide 6
CYP2E1 NM_000773 10q24.3-qter Cytochrome P450, subfamily IIE, polypeptide 1
CYP3A4 NM_017460 7q22.1 Cytochrome P450, subfamily IIIA, polypeptide 4
FMO1 NM_002021 1q23-q25 Flavin-containing monooxygenase 1
FMO5 NM_018578 1q21 Flavin-containing monooxygenase 5
LPO XM_042207 17q23.1 Lactoperoxydase
Phase II enzymes    
NQO1 NM_000903 16q22.1 NAD(P)H deshydrogenase, quinone 1
NAT1 NM_000662 8p23.1-p21.3 N-acetyltransferase 1
COMT NM_000754 22q11.21 Catechol-O-methyltransferase
EPHX1 NM_000120 1q42.1 Epoxyde hydrolase 1, microsomal
SULT1A1 NM_001055 16p12.1 Sulfotransferase family, cytosolic, 1A, member 1
SULT2A1 NM_003167 19q13.3 Sulfotransferase family, cytosolic, 2A, member 1
SULT2B1 NM_004605 19q13.3 Sulfotransferase family, cytosolic, 2B, member 1
UGT1A1 NM_000463 2q37 UDP-glucuronosyltransferase, 1 family, polypeptide A1
GSTP1 NM_000852 11q13 Glutathion S-transferase pi 1
GSTM1 NM_000561 1p13.3 Glutathion S-transferase mu 1
GSTM3 NM_000849 1p13.3 Glutathion S-transferase mu 3
GSTT1 NM_000853 22q11.23 Glutathion S-transferase theta 1
Phase III proteins    
ABCB1 NM_000927 7q21.1 ATP-binding cassette, subfamily B (MDR/TAP), member 1 (MDR1)
ABCC1 NM_004996 16p13.1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 (MRP1)
ABCC11 NM_033151 16q12.1 ATP-binding cassette, subfamily C (CFTR/MRP), member 11 (MRP8)
  1. a LocusLink symbol.