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Table 2 Univariate survival analysis (log-rank tests) of patient-related, tumor-related and therapy-related parameters

From: Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?

Parameter Distant metastasis-free survival P Disease-free survival P Overall survival P
Actuarial 5-year data (standard deviation) 49 (± 9)   50 (± 10)   59 (± 9)  
Age       
   <50 years 37 (± 15)   43 (± 14)   38 (± 16)  
   >50 years 52 (± 12) 0.09 51 (± 12) 0.09 69 (± 10) 0.06
T stage       
   T1/T2 66 (± 9)   68 (± 8)   75 (± 9)  
   T3/T4 16 (± 13) 0.001 16 (± 13) 0.003 26 (± 15) 0.01
Differentiation/grade       
   Moderate/G2 54 (± 12)   58 (± 11)   49 (± 15)  
   Poor/G3 42 (± 15) 0.40 42 (± 15) 0.52 67 (± 12) 0.84
Number of positive lymph nodes       
   1–3 64 (± 20)   60 (± 21)   80 (± 15)  
   ≥4 41 (± 10) 0.005 43 (± 10) 0.004 50 (± 11) 0.03
Estrogen receptor       
   Positive 57 (± 14)   58 (± 14)   63 (± 13)  
   Negative 37 (± 12) 0.04 36 (± 12) 0.03 52 (± 13) 0.14
Progesterone receptors       
   Positive 47 (± 20)   50 (± 21)   56 (± 16)  
   Negative 46 (± 10) 0.22 46 (± 11) 0.21 60 (± 12) 0.83
hif-1α expression       
   Intense 38 (± 15)   38 (± 15)   53 (± 17)  
   Moderate 48 (± 14)   50 (± 13)   50 (± 22)  
   No 56 (± 16) 0.12 58 (± 16) 0.13 66 (± 13) 0.46
hif-1α expression       
   Yes 43 (± 10)   44 (± 10)   55 (± 13)  
   No 56 (± 16) 0.04 58 (± 16) 0.04 66 (± 13) 0.21
  1. hif-1α, hypoxia-inducible factor 1 alpha.