From: Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?
Parameter | Distant metastasis-free survival | P | Disease-free survival | P | Overall survival | P |
---|---|---|---|---|---|---|
Actuarial 5-year data (standard deviation) | 49 (± 9) | 50 (± 10) | 59 (± 9) | |||
Age | ||||||
<50 years | 37 (± 15) | 43 (± 14) | 38 (± 16) | |||
>50 years | 52 (± 12) | 0.09 | 51 (± 12) | 0.09 | 69 (± 10) | 0.06 |
T stage | ||||||
T1/T2 | 66 (± 9) | 68 (± 8) | 75 (± 9) | |||
T3/T4 | 16 (± 13) | 0.001 | 16 (± 13) | 0.003 | 26 (± 15) | 0.01 |
Differentiation/grade | ||||||
Moderate/G2 | 54 (± 12) | 58 (± 11) | 49 (± 15) | |||
Poor/G3 | 42 (± 15) | 0.40 | 42 (± 15) | 0.52 | 67 (± 12) | 0.84 |
Number of positive lymph nodes | ||||||
1–3 | 64 (± 20) | 60 (± 21) | 80 (± 15) | |||
≥4 | 41 (± 10) | 0.005 | 43 (± 10) | 0.004 | 50 (± 11) | 0.03 |
Estrogen receptor | ||||||
Positive | 57 (± 14) | 58 (± 14) | 63 (± 13) | |||
Negative | 37 (± 12) | 0.04 | 36 (± 12) | 0.03 | 52 (± 13) | 0.14 |
Progesterone receptors | ||||||
Positive | 47 (± 20) | 50 (± 21) | 56 (± 16) | |||
Negative | 46 (± 10) | 0.22 | 46 (± 11) | 0.21 | 60 (± 12) | 0.83 |
hif-1α expression | ||||||
Intense | 38 (± 15) | 38 (± 15) | 53 (± 17) | |||
Moderate | 48 (± 14) | 50 (± 13) | 50 (± 22) | |||
No | 56 (± 16) | 0.12 | 58 (± 16) | 0.13 | 66 (± 13) | 0.46 |
hif-1α expression | ||||||
Yes | 43 (± 10) | 44 (± 10) | 55 (± 13) | |||
No | 56 (± 16) | 0.04 | 58 (± 16) | 0.04 | 66 (± 13) | 0.21 |