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Table 1 Distribution of patient-related, tumor-related and therapy-related parameters and cross-tabulations with hypoxia-inducible factor 1 alpha (hif-1α) expression

From: Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?

   hif-1α  
Parameter n (%) Negative Weak Strong P
Total 77 (100) 34 (44) 25 (33) 18 (23)  
Age      
   <50 years 23 (30) 8 (35) 10 (43) 5 (22) 0.38
   >50 years 54 (70) 26 (48) 15 (28) 13 (24)  
T stage      
   T1/T2 55 (71) 26 (48) 16 (30) 13 (22) 0.57
   T3/T4 22 (29) 8 (36) 9 (41) 5 (23)  
Differentiation/grade      
   Moderate/G2 43 (56) 20 (46) 12 (28) 11 (26) 0.68
   Poor/G3 32 (42) 12 (37) 13 (41) 7 (22)  
Number of lymph nodes      
   1–3 27 (35) 14 (52) 8 (30) 5 (18) 0.58
   ≥4 50 (65) 20 (40) 17 (34) 13 (26)  
Estrogen receptor      
   Positive 51 (66) 26 (51) 14 (27) 11 (22) 0.23
   Negative 26 (34) 8 (31) 11 (42) 7 (27)  
Progesterone receptor      
   Positive 41 (53) 25 (61) 9 (22) 7 (17) 0.006
   Negative 36 (47) 9 (25) 16 (44) 11 (31)  
Hormonotherapy      
   Yes 62 (81) 27(43) 19(31) 16(26) 0.56
   No 15 (19) 7(47) 6(40) 2(13)  
Chemotherapy      
   Yes 64 (83) 25(39) 23(36) 16(25) 0.13
   No 13 (17) 9(69) 2(15) 2(15)