Skip to main content

Advertisement

Table 1 Post-intravasation models for metastatic efficiency

From: Multistep tumorigenesis and the microenvironment

Peritoneal/venous shunts of ascitic fluid [14]
Site of primary tumor Average number of viable cells per 20 ml blood (delivered on average for 40 weeks) Average clonogenic efficiency in soft agar Metastatic events in patients at autopsy
Ovary, breast, pancreas bronchus, and colon 1 × 107 1 in 104 8/15: no viable cells
7/15: large number of single viable tumor cells and micrometastases in lung only
Tail injection [16, 17]
Cell types Gene expressed Number of cells per injection Lung colony efficiency
NIH-3T3 [16] c-H-ras 3 × 105 1 in 104
  v-src 3 × 105 2 in 105
MDA-MB-231 [17] - 1.0 × 106 <1 in 105
MDA-MB-435 [17] - 1.0 × 106 <1 in 105
  1. Data from references Tarin and coworkers [14], Egan and coworkers [16], and Price and coworkers [17].