TY - JOUR AU - Bernstein, Jonine L. AU - Langholz, Bryan AU - Haile, Robert W. AU - Bernstein, Leslie AU - Thomas, Duncan C. AU - Stovall, Marilyn AU - Malone, Kathleen E. AU - Lynch, Charles F. AU - Olsen, Jørgen H. AU - Anton-Culver, Hoda AU - Shore, Roy E. AU - Boice, John D. AU - Berkowitz, Gertrud S. AU - Gatti, Richard A. AU - Teitelbaum, Susan L. AU - Smith, Susan A. AU - Rosenstein, Barry S. AU - Børresen-Dale, Anne-Lise AU - Concannon, Patrick AU - Thompson, W. Douglas PY - 2004 DA - 2004/03/09 TI - Study design: Evaluating gene–environment interactions in the etiology of breast cancer – the WECARE study JO - Breast Cancer Research SP - R199 VL - 6 IS - 3 AB - Deficiencies in cellular responses to DNA damage can predispose to cancer. Ionizing radiation can cause cluster damage and double-strand breaks (DSBs) that pose problems for cellular repair processes. Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated. SN - 1465-542X UR - https://doi.org/10.1186/bcr771 DO - 10.1186/bcr771 ID - Bernstein2004 ER -