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Table 5 Multivariate Cox regression models for disease-free survival and overall survival in invasive lobular carcinoma patients

From: Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome

  DFS OS
Parameter RR (95% CI) P RR (95% CI) P
Nodes     
   0 1 <0.0001 1 <0.0001
   1–3 2.2 (1.6–3.2)   1.4 (1.1–1.9)  
   >3 4.1 (2.9–5.7)   2.2 (1.7–2.9)  
Tumor size (cm)     
   ≤2 1 <0.0001 1 <0.0001
   >2 1.9 (1.4–2.6)   1.6 (1.3–2.1)  
Age (years)     
   ≤50 - NS 1 <0.0001
   >50 -   2.3 (1.7–3.1)  
S-phase     
   Low 1 0.002 1 <0.0293
   Intermediate–high 1.7 (1.3–2.2)   1.3 (1.0–1.6)  
PgR     
   Positive 1 0.003 - NS
   Negative 1.5 (1.1–1.9)   -  
ER     
   Positive - NS 1 0.0006
   Negative -   1.9 (1.3–2.8)  
Ploidy     
   Diploid 1 0.03 - NS
   Aneuploid 1.7 (1.3–2.2)   -  
  1. CI, confidence interval; DFS, disease-free survival; ER, estrogen receptor; NS, not significant; OS, overall survival; PgR, progesterone receptor; RR, relative risk.