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Table 3 Behavior of LM38 cell lines in vivo

From: Malignant myoepithelial cells are associated with the differentiated papillary structure and metastatic ability of a syngeneic murine mammary adenocarcinoma model

Property LM38-LP LM38-HP LM38-D2
Subcutaneous tumor latency [median (range); days] 5 (5–19) 19 (19–61)* 24.5 (18–69)*
Subcutaneous tumor growth rate (mean ± SD; mm/day) 0.22 ± 0.04 0.05 ± 0.01* 0.11 ± 0.02*
Incidence of spontaneous lung metastases (%) 9/9 (100) 4/8* (50) 1/8* (12.5)
Incidence of spontaneous lymph node metastases (%) 5/9 (55.5) 1/8* (12.5) 0/8* (0)
No. of experimental lung metastases [median (range)] 40.5 (9–80) 0 (0–3)* 0 (0–1)*
  1. The representative data shown correspond to one of three independent experiments. Mice were inoculated with 2 × 105 cells for subcutaneous tumor growth and assessment of spontaneous metastasizing ability, or with 3 × 105 cells for the experimental metastasis assay. *P < 0.05 compared with LM38-LP.