Malignant myoepithelial cells are associated with the differentiated papillary structure and metastatic ability of a syngeneic murine mammary adenocarcinoma model

Table 3 Behavior of LM38 cell lines in vivo

Property	LM38-LP	LM38-HP	LM38-D2
Subcutaneous tumor latency [median (range); days]	5 (5–19)	19 (19–61)*	24.5 (18–69)*
Subcutaneous tumor growth rate (mean ± SD; mm/day)	0.22 ± 0.04	0.05 ± 0.01*	0.11 ± 0.02*
Incidence of spontaneous lung metastases (%)	9/9 (100)	4/8* (50)	1/8* (12.5)
Incidence of spontaneous lymph node metastases (%)	5/9 (55.5)	1/8* (12.5)	0/8* (0)
No. of experimental lung metastases [median (range)]	40.5 (9–80)	0 (0–3)*	0 (0–1)*

The representative data shown correspond to one of three independent experiments. Mice were inoculated with 2 × 10⁵ cells for subcutaneous tumor growth and assessment of spontaneous metastasizing ability, or with 3 × 10⁵ cells for the experimental metastasis assay. *P < 0.05 compared with LM38-LP.

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