Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression

Table 4 Cell death-related genes in lactation and involution clusters

	Inv1??	Inv2??	Inv3??	Inv4??	Lac 1??	Lac2??	Lac3??
Cell survival	Prdx2	Nfkb2	Api5	Bcl2l (BclX)	Psap	Akt1
	Bcl10		Ank3	Mcl1	Birc4(mXIAP)	Dad1
				Psap		Gfi1
Cell death	Hrk	Bcl2l10 (Diva)	Fsp27	Igfbp5	Tnip1 (ABIN1)		Tnfrsf11a(Rank)
	Gzmb	Casp4 (casp11)	Bax	Casp1	Eya2		Cidea
	Nkx3-1	Casp12	Casp7	Foxm1	Tial1		Dffb
	Tnfsf6(FasL)	Gadd45b	Serpinb5	Apaf1	Dapk3		Perp-pending
	Lsp1	Pdcd6	Pdcd6	Gzma	Foxb1		Traf6
	Tnfsf4(OX40L)	Cdkn1a (p21)	Pdcd5	Tia1	Rbl2		Tnfsf9
	Tnfsf7 (Cd27l)	Unc5	Tnfrsf6 (Fas)	Phlda1	Tnfsf5 (TRAP)
	Tnfsf10 (Trail)	Foxb2	Fadd	Tnfrsf4 (Ox40)
	Tnfsf12 (Tweak)	Mycs (s-myc)	Myd88	Tgfb1
	Tnfrsf9 (Cd137)	E4bp4	Tnfrsf1a
	Tnf (Tnfa)	Ngfa
		Ltbr

The identity of cell death-related transcripts was determined for each of the profile clusters illustrated in Fig. 4. Thus, transcripts belonging to the ontological category apoptosis or cell death from each cluster were listed according to their expected role as proapoptotic or survival factors. All gene names conform to the mouse genome informatics database [23], and synonyms are included in brackets where appropriate. A complete genelists for this apoptosis category is available on GeNet (see Method section).

ISSN: 1465-542X