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Figure 6 | Breast Cancer Research

Figure 6

From: Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action

Figure 6

Interaction of phenolic acids with the aryl hydrocarbon receptor (AhR). (a) Interaction of 10-7 M phenolic acids on the AhR against TCDD. (b) Competition of caffeic acid on aryl hydrocarbon binding. Homologous displacement with TCDD given for comparison. (c) Inhibition of basal and TCDD-stimulated CYP1A1 (O-dealkylation of ethoxyresorufin [EROD]) activity by 10-7 M caffeic acid. (d) Dose effect of caffeic acid on the (EROD) activity of CYP1A1, after 24 hours of incubation. The time course of (e) the basal and (f) the TCDD-stimulated CYP1A1 transcript, after application of 10-7 M caffeic acid. RT-PCR data were normalized for actin, and divided by the corresponding control values (control = 1 in all cases). PAA, 3,4-dihydroxy-phenylacetic acid.

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Breast Cancer Research

ISSN: 1465-542X

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