Figure 1From: Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapySchematic diagram of the two human estrogen receptors, ERα and ERβ. Both receptors consist of six functional domains, including the DNA-binding domain (DBD), the ligand-binding domain (LBD), the ligand-independent activation function AF-1, and the ligand-dependent activation function AF-2. The percentage identity between the two receptors is indicated.Back to article page