Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

Table 5 Prognostic factors in 470 invasive ductal carcinomas compared with overall survival

	Univariate	Multivariate
Parameter	P	P	RR (95% CI)
Tumor size	< 0.0001	0.008	0.470 (0.273–0.809)
Number of positive lymph nodes	< 0.0001	< 0.0001	0.275 (0.157–0.482)
Histological grade	< 0.0001	0.09	0.665 (0.419–1.056)
Estrogen receptor-α	0.002	0.16	1.389 (0.866–2.229)
HER2/p53	< 0.0001	0.04	0.565 (0.323–0.990)
Ki67	0.28
Adjuvant therapy	0.0001	0.75	0.879 (0.400–1.930)

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