Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

Table 4 Prognostic factors in 470 invasive ductal carcinomas compared with disease free survival

	Univariate	Multivariate
Parameter	P	P	RR (95% CI)
Tumor size	< 0.0001	0.02	0.626 (0.418–0.938)
Number of positive lymph nodes	< 0.0001	< 0.0001	0.227 (0.144–0.359)
Histological grade	< 0.0001	0.09	0.712 (0.479–1.057)
Estrogen receptor-α	0.03	0.42	1.176 (0.787–1.756)
HER2/p53	< 0.0001	0.06	0.630 (0.391–1.017)
Ki67	0.001	0.003	0.589 (0.416–0.833)
Adjuvant therapy	< 0.0001	0.76	1.098 (0.606–1.988)

ISSN: 1465-542X