Table 2 Correlation between clinicopathologic factors and molecular markers
| Â | HER2 | p53 | Ki67 | |||
|---|---|---|---|---|---|---|
Parameter | Positive/total (n [%]) | P | Positive/total (%) | P | Positive/total (%) | P |
Total | 104/503 (20.1) | Â | 145/500 (29.0) | Â | 268/500 (53.6) | Â |
Tumor size (cm) | Â | Â | Â | Â | Â | Â |
   < 2.0 | 30/208 (14.4) | 0.004 | 44/209 (21.1) | 0.0009 | 110/209 (52.6) | NS |
   ≥ 2.0 | 74/295 (25.1) |  | 101/291 (34.7) |  | 158/291 (54.3) |  |
Number of positive lymph nodes | Â | Â | Â | Â | Â | Â |
   0 | 47/276 (17.0) | 0.006 | 72/274 (26.3) | NS | 145/274 (52.9) | NS |
   1–3 | 21/115 (18.3) |  | 32/114 (28.1) |  | 62/114 (54.4) |  |
   > 3 | 30/93 (32.3) |  | 36/92 (39.1) |  | 48/92 (52.2) |  |
Histological grade | Â | Â | Â | Â | Â | Â |
   1 | 5/93 (5.4) | < 0.0001 | 7/91 (7.7) | < 0.0001 | 39/91 (42.9) | 0.004 |
   2 | 291/58 (19.9) |  | 82/291 (28.2) |  | 151/291 (51.9) |  |
   3 | 40/116 (34.5) |  | 55/116 (47.4) |  | 76/116 (65.5) |  |
Estrogen receptor-α |  |  |  |  |  |  |
   Negative | 70/163 (42.9) | < 0.0001 | 77/162 (47.5) | < 0.0001 | 90/162 (55.6) | NS |
   Positive | 34/339 (10.0) |  | 68/340 (20.0) |  | 179/340 (52.6) |  |