Table 3 Effect of estrogen metabolites on mammary carcinogenesis
From: Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments
Treatment | Duration | Mammary cancer incidence | Rats with mammary cancer (%) | Average number of cancers per rat |
|---|---|---|---|---|
Control | 3 weeks | 9/12 | 75 | 1.3 ± 0.5 |
2 mg 2-hydroxy estradiol | 3 weeks | 8/10 | 80 | 1.4 ± 0.3 |
2 mg 2-hydroxy estradiol + 30 mg progesterone | 3 weeks | 6/10 | 60 | 1.5 ± 0.5 |
2 mg 2-methoxy estradiol | 3 weeks | 6/10 | 60 | 0.7 ± 0.2 |
2 mg 2-methoxy estradiol + 30 mg progesterone | 3 weeks | 3/10* | 30 | 0.4 ± 0.2 |