From: BRCA1 and BRCA2 mutations in central and southern Italian patients
Age of proband at disease diagnosis | ||||||||
---|---|---|---|---|---|---|---|---|
40 years or less | 41-50 years | 51 years or more | All ages | |||||
Cancer patients | BRCA1 | BRCA2 | BRCA1 | BRCA2 | BRCA1 | BRCA2 | BRCA1 | BRCA2 |
in family† | [% (n)] | [% (n)] | [% (n)] | [% (n)] | [% (n)] | [% (n)] | [% (n)] | [% (n)] |
Breast | ||||||||
One | 4 (1/28) | 4 (1/28) | 0 (0/9)* | 0 (0/9)* | 0 (0/10)* | 0 (0/10)* | 2 (1/47)* | 2 (1/47)* |
Two or three | 25 (2/8) | 0 (0/8) | 0 (0/13) | 0 (0/13) | 3 (1/34) | 9 (3/34) | 5 (3/55) | 5 (3/55) |
Total | 8 (3/36) | 3 (1/36) | 0 (0/22) | 0 (0/22) | 2 (1/44) | 7 (3/44) | 4 (4/102) | 4 (4/102) |
Breast/ovary | ||||||||
None/one | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/3) | 0 (0/3) | 0 (0/5) | 0 (0/5) |
None to two/ | - | - | 25 (1/4) | 0 (0/4) | 0 (0/6) | 0 (0/6) | 10 (1/10) | 0 (0/10) |
one or two | ||||||||
Total | 0 (0/1) | 0 (0/1) | 20 (1/5) | 0 (0/5) | 0 (0/9) | 0 (0/9) | 7 (1/15) | 0 (0/15) |