Chance that a mutation is present* | Clinical criteria |
---|---|
<10% | All single cases of breast or ovarian cancer |
10% | Single breast cancer cases aged <35 years |
>10-≤ 30% | Two breast cancer cases aged <50 years |
 | One breast cancer case aged <40 years in an |
 | Ashkenazi jew |
≤ 50% | Three breast cancer cases aged <50 years |
 | Four to five breast cancer cases, no ovarian cancer |
 | One breast and ovarian cancer case |
>50% | More than one breast and ovarian cancer case |
 | At least four cases of female/male breast cancer |
 | More than six female breast cancer cases |