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Figure 7 | Breast Cancer Research

Figure 7

From: Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion

Figure 7

Comparison of the loss of heterozygosity (LOH) pattern in estrogen receptor (ER)-negative cells and adjacent ER-positive cells within the same duct. (a) H & E staining of a duct with atypical intraductal hyperplasia, 200×; (b) the adjacent section of (a) immunostainined (before microdissection), 200×; (c) microdissection of ER-positive cells; (d) microdissection of ER-negative cells; (e) LOH at four selected DNA markers. Asterisks indicate the ER-negative cells and the ER-positive cells removed; arrows identify LOH.

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Breast Cancer Research

ISSN: 1465-542X

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