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Table 1 Patient and tumour characteristics and relationship with HIF-1α, sHIF-1α and aHIF mRNA expression concentration

From: aHIF but not HIF-1α transcript is a poor prognostic marker in human breast cancer

Parameter

Value

n (%)

HIF-1

 

sHIF-1

 

aHIF

 

Age (years)

<50

55 (50)

0.25 ± 0.03

P = 0.66

0.09 ± 0.01

P = 0.53

0.23 ± 0.05

P = 0.66

 

≥ 50

55 (50)

0.22 ± 0.03

 

0.11 ± 0.02

 

0.24 ± 0.04

 

T stage

1

4 (4)

0.18 ± 0.05

P = 0.49

0.04 ± 0.01

P = 0.30

0.08 ± 0.05

P = 0.010

 

2

73 (66)

0.22 ± 0.03

 

0.09 ± 0.01

 

0.26 ± 0.02

 
 

3

21 (19)

0.16 ± 0.03

 

0.08 ± 0.02

 

0.45 ± 0.07

 
 

4

12 (16)

0.31 ± 0.03

 

0.20 ± 0.02

 

0.45 ± 0.13

 

Node status (clinical)

-

43 (39)

0.15 ± 0.03

P = 0.036

0.07 ± 0.01

P = 0.11

0.21 ± 0.05

P = 0.20

 

+

66 (61)

0.25 ± 0.03

 

0.12 ± 0.02

 

0.25 ± 0.04

 

Histological type

IDC

91 (83)

0.23 ± 0.03

P = 0.006

0.10 ± 0.01

P = 0.74

0.21 ± 0.03

P = 0.38

 

ILC

11 (10)

0.05 ± 0.02

 

0.07 ± 0.01

 

0.44 ± 0.16

 

SBR grade

I

13 (15)

0.24 ± 0.07

P = 0.26

0.12 ± 0.04

P = 0.20

0.31 ± 0.14

P = 0.83

 

II

44 (50)

0.26 ± 0.04

 

0.12 ± 0.02

 

0.20 ± 0.04

 
 

III

31 (35)

0.16 ± 0.04

 

0.06 ± 0.01

 

0.16 ± 0.03

 

S phase

<10%

48 (58)

0.22 ± 0.04

P = 0.40

0.10 ± 0.02

P = 0.97

0.19 ± 0.06

P = 0.018

 

≥ 10%

35 (42)

0.19 ± 0.04

 

0.08 ± 0.02

 

0.28 ± 0.05

 

Oestrogen receptors

+

51 (56)

0.17 ± 0.03

P = 0.02

0.09 ± 0.02

P = 0.097

0.23 ± 0.05

P = 0.49

 

-

40 (44)

0.29 ± 0.04

 

0.12 ± 0.02

 

0.22 ± 0.05

 

Progesterone receptors

+

24 (26)

0.18 ± 0.04

P = 0.33

0.09 ± 0.02

P = 0.14

0.26 ± 0.09

P = 0.54

 

-

67 (74)

0.24 ± 0.03

 

0.11 ± 0.01

 

0.22 ± 0.04

 

HER2

+

18 (21)

0.29 ± 0.06

P = 0.039

0.13 ± 0.03

P = 0.23

0.19 ± 0.07

P = 0.92

 

-

66 (79)

0.17 ± 0.03

 

0.08 ± 0.01

 

0.23 ± 0.05

 

p53

≤ 10%

45 (75)

0.17 ± 0.03

P = 0.20

0.08 ± 0.02

P = 0.48

0.23 ± 0.06

P = 0.37

 

>10%

15 (25)

0.22 ± 0.04

 

0.07 ± 0.01

 

0.21 ± 0.07

 
  1. IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; SBR, Scarff, Bloom and Richardson. For HIF-1, sHIF-1 and aHIF, results were expressed by relative expression (REx) as mean ± standard error (SE). The final sums are not always equal to 110 patients because of some non-available data.