From: aHIF but not HIF-1α transcript is a poor prognostic marker in human breast cancer
Parameter | Value | n (%) | HIF-1 | sHIF-1 | aHIF | |||
---|---|---|---|---|---|---|---|---|
Age (years) | <50 | 55 (50) | 0.25 ± 0.03 | P = 0.66 | 0.09 ± 0.01 | P = 0.53 | 0.23 ± 0.05 | P = 0.66 |
≥ 50 | 55 (50) | 0.22 ± 0.03 | 0.11 ± 0.02 | 0.24 ± 0.04 | ||||
T stage | 1 | 4 (4) | 0.18 ± 0.05 | P = 0.49 | 0.04 ± 0.01 | P = 0.30 | 0.08 ± 0.05 | P = 0.010 |
2 | 73 (66) | 0.22 ± 0.03 | 0.09 ± 0.01 | 0.26 ± 0.02 | ||||
3 | 21 (19) | 0.16 ± 0.03 | 0.08 ± 0.02 | 0.45 ± 0.07 | ||||
4 | 12 (16) | 0.31 ± 0.03 | 0.20 ± 0.02 | 0.45 ± 0.13 | ||||
Node status (clinical) | - | 43 (39) | 0.15 ± 0.03 | P = 0.036 | 0.07 ± 0.01 | P = 0.11 | 0.21 ± 0.05 | P = 0.20 |
+ | 66 (61) | 0.25 ± 0.03 | 0.12 ± 0.02 | 0.25 ± 0.04 | ||||
Histological type | IDC | 91 (83) | 0.23 ± 0.03 | P = 0.006 | 0.10 ± 0.01 | P = 0.74 | 0.21 ± 0.03 | P = 0.38 |
ILC | 11 (10) | 0.05 ± 0.02 | 0.07 ± 0.01 | 0.44 ± 0.16 | ||||
SBR grade | I | 13 (15) | 0.24 ± 0.07 | P = 0.26 | 0.12 ± 0.04 | P = 0.20 | 0.31 ± 0.14 | P = 0.83 |
II | 44 (50) | 0.26 ± 0.04 | 0.12 ± 0.02 | 0.20 ± 0.04 | ||||
III | 31 (35) | 0.16 ± 0.04 | 0.06 ± 0.01 | 0.16 ± 0.03 | ||||
S phase | <10% | 48 (58) | 0.22 ± 0.04 | P = 0.40 | 0.10 ± 0.02 | P = 0.97 | 0.19 ± 0.06 | P = 0.018 |
≥ 10% | 35 (42) | 0.19 ± 0.04 | 0.08 ± 0.02 | 0.28 ± 0.05 | ||||
Oestrogen receptors | + | 51 (56) | 0.17 ± 0.03 | P = 0.02 | 0.09 ± 0.02 | P = 0.097 | 0.23 ± 0.05 | P = 0.49 |
- | 40 (44) | 0.29 ± 0.04 | 0.12 ± 0.02 | 0.22 ± 0.05 | ||||
Progesterone receptors | + | 24 (26) | 0.18 ± 0.04 | P = 0.33 | 0.09 ± 0.02 | P = 0.14 | 0.26 ± 0.09 | P = 0.54 |
- | 67 (74) | 0.24 ± 0.03 | 0.11 ± 0.01 | 0.22 ± 0.04 | ||||
HER2 | + | 18 (21) | 0.29 ± 0.06 | P = 0.039 | 0.13 ± 0.03 | P = 0.23 | 0.19 ± 0.07 | P = 0.92 |
- | 66 (79) | 0.17 ± 0.03 | 0.08 ± 0.01 | 0.23 ± 0.05 | ||||
p53 | ≤ 10% | 45 (75) | 0.17 ± 0.03 | P = 0.20 | 0.08 ± 0.02 | P = 0.48 | 0.23 ± 0.06 | P = 0.37 |
>10% | 15 (25) | 0.22 ± 0.04 | 0.07 ± 0.01 | 0.21 ± 0.07 |