E-cadherin is accumulated in the cytoplasm of primary and metastatic lobular carcinomas of the breast. (A) and (B) Primary invasive lobular carcinoma invading fat. Notice the cellular discohesion and vacuolization typical of invasive lobular carcinomas. This tumor has cytoplasmic accumulation of E-cadherin. (C) Distant metastasis to the liver 8 years later exhibiting the pattern of E-cadherin expression as the primary tumor. 200 × magnification.