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Table 1 Commonly used breast cancer xenograft models

From: Models of breast cancer: is merging human and animal models the future?

Human breast cancer xenograft model Description Reference
MCF-7 Breast adenocarcinoma cell line, oestrogen receptor-positive [37]
MCF-7/6 Oestrogen sensitive [38]
MCF-7 BAG Immunodeficient xenograft model [39]
MCF-7/hVEGF hVEGF overexpressing  
MCF-7-TAM LT Long-term tamoxifen-stimulated breast tumour model [40]
MCF-7/neu Overexpressing oncogene neu [41]
MCF-7-MIII Oestrogen sensitive [42]
MCF-7Ca Transfected with human aromatase gene [43]
MT2 MCF-7 tamoxifen-stimulated tumour with Asp351Tyr mutant oestrogen receptor [44]
MT2 TAM MCF-7-derived tumour serially passaged with tamoxifen [40]
MT-1 Oestrogen and progesterone receptor-negative in nude rats [45]
MT-3 Oestrogen receptor-negative [45]
LY2 Anti-oestrogen-resistant variant of MCF-7 [46]
UMB-1Ca Oestrogen-independent variant of MCF-7 [47]
MDA-MB-231 Oestrogen independent [48]
MDA-MD-231 BAG Immunodeficient xenograft model [39]
MDA-MB-361 Brain metastasis-derived breast adenocarcinoma cell line [49]
MDA-MB-435 Oestrogen receptor-negative [48]
MDA-MB-435A Ascites model [50]
MDA-MB-435S Spindle-shaped strain of parent line [51]
MDA-MD-435 BAG Immunodeficient xenograft model [39]
MDA-MB-453 BAG Fibroblast growth factor receptor overexpressing [39]
MDA-453/LCC6   [52]
MDA-MB-468 Oestrogen receptor-negative metastasis-derived cell line [49]
MDA-MB-453 Breast adenocarcinoma cell line [53]
MCF10AT Preneoplastic and proliferative model; nontumourigenic [54]
MCF10AneoN Transfected with neomycin-resistance gene [55]
MCF10AneoT T24-Ha-ras-transformed derivative of MCF10A [55] Comedo ductal carcinoma in situ [56]
MC-2   [57]
MC-5   [57]
MC-18   [57]
SK-BR3 Breast adenocarcinoma cell line that overexpresses oncogenic protein p185HER2; oestrogen receptor-negative [58]
SK-BR3/hVEGF VEGF overexpressing cell line [58]
BT-20 Oestrogen receptor-negative [37]
BT-474 Erb2 overexpressing breast tumour [59]
ZR-75-1 Oestrogen-dependent breast carcinoma [60]
SUM149 Inflammmatory breast cancer cell line [61]
SUM159PT Oestrogen independent [62]
T47D Oestrogen receptor-positive [63]
T47D-E2 Tamoxifen naïve tumour [63]
KPL-1 Oestrogen receptor-positive [64]
KPL-4 Oestrogen receptor-negative [65]
MaTu Oestrogen receptor-negative solid human mammary carcinoma cell line [45]
MC4000 Oestrogen receptor-negative [45]
HT-39 Oestrogen receptor-negative [66]
HX99   [67]
T61 Oestrogen receptor-positive ductal carcinoma [68]
B37   [69]
BO Oestrogen receptor-positive [70]
Br10   [71]
SE   [71]
WIBC-9 Inflammmatory breast cancer cell line [57]
Met-1 Metastatic breast cancer cell line  
MAXF401   [72]
MX-1   [73]
MAXF 499 Solid ductal [74]
NCI/ADR or MCF-7/ADR Multidrug-resistant MCF-7 cell line that overexpresses P-glycoprotein [75]
4296 Oestrogen receptor-positive [76]
4049 Oestrogen receptor-negative [76]
4151   [75]
4134   [75]
3366   [77]
4000   [77]
CAL51 Metastatic model of adenocarcinoma [78]
MA-11 Oestrogen and progesterone negative receptor in nude rats [79]
H31   [80]
MARY-X Inflammatory breast cancer model [81]
HBT 3477 Adenocarcinoma [82]
Hs578T Carcinosarcoma derived, epithelial in origin [82]
C8161 Breast cancer line with high levels of spontaneous metastasis [83]
M24met Breast cancer line with high levels of spontaneous metastasis [83]
CaMa 15 Primary infiltrating ductal breast carcinoma [37]
MaNo 4 Medullary breast carcinoma [37]
GI-101 Metastatic breast tumour line [25]
UISO-BCA-NMT-18 Primary breast carcinoma [84]
  1. VEGF, vascular endothelial growth factor.