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Table 6 Observed and expected numbers of mutation carriers, as predicted by the LAMBDA model, for categories based on predicted range of probability of being a carrier

From: Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA)

Predicted range

 

Numbers of carriers (percentage)

λ

Probability (%)

Number of women

Observed

Expected

<-3.5

<2

128

5 (4%)

2.1 (2%)

-3.5 to -2.25

2–10

117

12 (10%)

7.2 (6%)

-2.0 to -1.25

10–25

84

11 (13%)

13.4 (16%)

-1.0 to -0.25

25–50

59

14 (24%)

20.1 (34%)

0.0 to 0.75

50–75

30

16 (53%)

18.2 (61%)

≥ 1.0

≥ 75

6

6 (100%)

5.1 (85%)

Total

 

424

64 (15%)

66.2 (16%)