Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA)

Table 5 Logistic regression coefficients (β), standard errors and nominal significance levels for potentially predictive factors for an Ashkenazi Jewish woman having an ancestral mutation in BRCA1 or BRCA2, derived from multiple linear logistic regression

Characteristic	β	Standard error	P
Baseline	-3.767	0.436	0.001
Proband breast cancer diagnosis <40 years	2.570	0.523	0.0001
Proband breast cancer diagnosis 40–49 years	1.707	0.455	0.0002
Proband breast cancer diagnosis 50–59 years	0.493	0.602	0.4
Proband breast cancer diagnosis 60+ years	0.578	0.598	0.3
Proband bilateral breast cancer at any age	0.912	0.500	0.07
Proband ovarian cancer at any age	2.621	0.570	0.0001
For each relative with cancer
1st degree, breast cancer diagnosis <40 years	1.790	0.637	0.005
1st degree, breast cancer diagnosis 40–49 years	1.154	0.438	0.008
1st degree, breast cancer diagnosis 50–59 years	1.227	0.419	0.003
1st degree, breast cancer diagnosis 60+ years	0.033	0.482	0.9
1st degree, ovarian cancer at any age	1.339	0.454	0.003
2nd degree, breast cancer diagnosis <40 years	0.892	0.591	0.13
2nd degree, ovarian cancer at any age	1.004	0.489	0.04
1st or 2nd degree, bilateral breast cancer at any age	-0.088	0.572	0.9

ISSN: 1465-542X