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Table 4 Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and having a relative with breast cancer with given age at diagnosis, for first-degree relatives and for second-degree relatives

From: Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA)

 

Age at diagnosis for first-degree relatives with breast cancer

Age at diagnosis for second-degree relatives with breast cancer

Cancer status

<40 years

40–49 years

50–59 years

60 years or older

<40 years

40–49 years

50–59 years

60 years or older

No breast or ovarian cancer

3/15 (20%)

4/29 (14%)

4/34 (12%)

0/28 (0%)

1/6 (17%)

2/23 (9%)

2/19 (11%)

1/32 (3%)

Breast cancer only

3/6 (50%)

7/23 (30%)

7/21 (33%)

5/30 (17%)

3/8 (38%)

4/16 (25%)

3/24 (13%)

5/52 (10%)

Ovarian cancer only

1/1 (100%)

0/1 (0%)

0/1 (0%)

0/2 (0%)

0/0 (-)

0/2 (0%)

2/2 (100%)

1/3 (33%)

Breast and ovarian cancer

0/0 (-)

-

1/1 (100%)

-

-

-

-

-