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Table 3 Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and number of first-degree relatives with ovarian cancer, and with number of second-degree relatives with ovarian cancer

From: Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA)

 

No. of first-degree relatives with ovarian cancer

No. of second-degree relatives with ovarian cancer

Cancer status

0

1

2

0

1

2

No breast or ovarian cancer

10/131 (8%)

8/89 (9%)

0/7 (0%)

11/144 (8%)

1/4 (25%)

-

Breast cancer only

34/237 (14%)

13/42 (31%)

-

38/242 (16%)

4/5 (80%)

0/3 (0%)

Ovarian cancer only

4/18 (22%)

3/4 (75%)

-

5/20 (25%)

2/2 (100%)

-

Breast and ovarian cancer

3/3 (100%)

0/1 (0%)

-

3/4 (75%)

-

-