Table 2 Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and number of first-degree relatives with breast cancer, and number of second-degree relatives with breast cancer
| Â | No. of first-degree relatives with breast cancer | No. of second-degree relatives with breast cancer | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Cancer status | 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | 4 | 5 |
No breast or ovarian cancer | 1/47 (2%) | 11/94 (12%) | 0/7 (0%) | - | 6/77 (7%) | 5/56 (9%) | 1/14) (7% | 0/1 (0%) | - | - |
Breast cancer only | 22/175 (13%) | 16/66 (24%) | 4/8 (50%) | 0/1 (0%) | 30/165 (18%) | 9/64 (14%) | 1/15 (7%) | 1/5 (20%) | - | 1/1 (100%) |
Ovarian cancer only | 6/17 (35%) | 1/5 (20%) | - | - | 5/17 (29%) | 2/4 (50%) | - | - | 0/1 (0%) | - |
Breast and ovarian cancer | 2/3 (67%) | 1/1 (100%) | - | - | 1/1 (100%) | 2/3 (67%) | - | - | - | - |