Table 1 Proportions of probands with a germline ancestral mutation in BRCA1 or BRCA2 out of total tested (percentages in parentheses), by personal cancer history and age at testing in unaffected women, or age at first diagnosis in affected women
| Â | Age group* | Â | Â | |||
|---|---|---|---|---|---|---|
Cancer status | Under 40 years | 40–49 years | 50–59 years | 60 years or older | Total | Median age (years) |
No breast or ovarian cancer | 6/50 (12%) | 3/48 (6%) | 2/33 (6%) | 1/17 (6%) | 12/148 (8%) | 44 |
Breast cancer only | 15/40 (38%) | 19/89 (21%) | 4/68 (6%) | 4/53 (8%) | 42/250 (17%) | 49 |
Ovarian cancer only | 0/8 (0%) | 3/6 (50%) | 2/5 (40%) | 2/3 (67%) | 7/22 (32%) | 44 |
Breast and ovarian cancer | 0/0 (-) | 1/1 (100%) | 1/1 (100%) | 1/2 (50%) | 3/4 (75%) | 59 |
Total | 21/98 (21%) | 26/144 (18%) | 9/107 (8%) | 8/75 (11%) | 64/424 (15%) | Â |