Table 2 Genes not previously reported to be regulated by transforming growth factor beta (TGF-β)

Cellular communication

Cell cycle regulator

   Gadd45g

Up***

Up*

Up*

   Calcyclin binding protein (CACYBP)

Up*

No

Up*

   cdc2

No

Up*

Up*

   E2F transcription factor 5 (E2f5)

Down*

Down*

Down*

   Hsp84-1

No

Up*

Up*

Cancer

   Junctional adhesion molecule (Jam)

No

Up*

Up*

   Suppression of tumorigenicity 13

No

Up*

Up*

   Catenin α1 (Catna1)

No

Up*

Up*

   Candidate tumor suppressor p33 ING1

No

Up*

Up*

Signal transduction

Transport

   NFKBIL2 gene for IκBR

No

Down***

Down**

   Solute carrier family 4

Up**

Up**

Up*

   GTPase-activating protein GIT1

Up*

Up*

No

   ATPase, H⁺ transporting (ATP6J)

No

Up*

Up*

   Ras-GTPase-activating SH3 binding

Up**

No

Up*

   Ca²⁺/calmodulin-dependent kinase I

Up*

Up***

Up**

   Ikki

Down*

Down*

Down*

Microtubular dynamics

   Iqgap1

Up*

Up**

Up**

   Kinesin light chain 1 (Klc1)

Up*

No

Up*

   Milk fat globule-EGF factor 8 protein

No

Up*

Up**

   Microtubule-associated protein 4

Up**

Up**

Up**

   Tnfrh1 gene

Up*

No

Up*

Ubiquitin and elongation factors

Intracellular components

   Ubiquitin-specific protease 5 (Usp5)

Up**

Up*

Up*

   Actinin α3 (Actn3)

Up*

Up**

Up*

   Elongation factor 1-alpha (EF 1-α)

No

Up**

Up***

   Actin-related protein 2/3 complex

Up*

Up*

Up*

Chaperone

   Unconventional myosin-15 gene

Up*

No

Up**

   Ccth gene for chaperonin

Up*

Up*

Up**

   Nonmuscle tropomyosin 5

No

Up*

Up*

   Chaperonin subunit 7 (Cct7)

Up*

Up*

Up**

   Melanoma X-actin (Actx)

No

Up*

Up**

Enzyme

   Tropomyosin isoform 2

No

Up*

Up**

   Phosphoserine aminotransferase

No

Down**

Down**

   Actin-related protein 1

No

Up*

Up**

   α-methylacyl coenzyme (Macr1)

No

Down**

Down**

   Karyopherin β3 (KPNB3)

No

No

Up*

   PLC-L2 for phospholipase C-L2

No

Down**

Down**

   β-tropomyosin 2

No

Up*

Up***

   Fatty acid coenzyme A ligase (FACL4)

No

Down**

Down**

   TM-4 gene for fibroblast tropomyosin 4

No

Up**

Up**

   Phospholipase A2, group 4 (Pla2g4)

No

No

Up*

   Calpain

No

Up**

Up**

   Serine/threonine kinase (Unc51.1)

No

Up*

Up**

   Myosin light chain 2 (Mlc2)

No

Up*

No

   Proteasome (Psmd13)

Up**

Up*

Up*

Extracellular components

   Na, K-ATPase α-1

No

Up**

Up*

   Cis-Golgi matrix protein GM130

Up**

No

Up*

   Aldehyde dehydrogenase 5 (ALDH5)

Up*

Up*

No

   α-1(XVIII) collagen (COL18A1)

No

Up*

Up**

   Protein phosphatase 2A (PR 53)

Up*

No

Up*

   Smarce1

No

Up*

Up*

   Casein kinase 1 (Csnk1e)

Up*

Up*

Up***

Nucleic acid binding

   Serine/threonine phosphatase-2C

Up*

No

No

   HNRPM

Up*

Up*

No

   Coatomer protein (Copg1)

Up*

Up*

Up*

   Hnrpu

No

Up*

Up*

   MAP kinase kinase 3b

Up**

No

No

   Hnrnpc

Up*

Up*

Up*

   Protein phosphatase 1 (Ppp1cc)

No

Up*

No

   Damage-specific DNA binding (Ddb1)

Up*

Up**

Up***

   Na, K-ATPase β-subunit

No

Up**

Up*