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Figure 1 | Breast Cancer Research

Figure 1

From: Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

Figure 1

Proposed spatial organization of the extracellular matrix (ECM) and integrin function during mammary gland branching morphogenesis. The composition of the ECM that surrounds developing ducts and the type of integrin that relays signals from the ECM would depend on the morphogenic event. Areas requiring invasion and proliferation and low adhesion (TEBs [terminal end buds], side branching) would have a unique ECM/integrin profile compared with areas that are dormant (primary ducts, noninvasive end buds). Unique signals in areas that may require stem or progenitor cell differentiation may require specific ECM-integrin profiles, unlike other areas.

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Breast Cancer Research

ISSN: 1465-542X

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