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Table 2 Cancer incidence in first-degree relatives of index cases with breast cancer younger than age 41 but noBRCA1/BRCA2 germline mutation, and at least one additional case of breast cancer in a first-degree or second-degree relative

From: Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2mutation status

ICD-7 Site Observed (n) Expected (n) Standardized incidence ratio 95% confidence interval
140–209 All malignant tumours 43 18.5 2.3 1.6–3.1
Non-170 All malignant tumours except breast 29 15.9 1.8 1.2–2.6
153 Large bowel 1 1.2 0.82 0.02–4.6
154 Rectum 2 0.82 2.4 0.30–8.8
162 Trachea and lung 3 1.5 2.0 0.42–5.9
170 Breast 14 2.6 5.3 2.9–9.0
171 Cervix uteri 2 0.39 5.1 0.62–18.5
175 Ovaries 1 0.50 2.0 0.05–11.0
177 Prostate 6 2.4 2.5 0.91–5.4
180 Kidney 2 0.74 2.7 0.33–9.8
181 Bladder and urinary tract 2 0.93 2.1 0.26–7.8
191 Skin nonmelanoma 1 0.50 2.0 0.05–11.2
193 Central nervous system 2 0.86 2.3 0.28–8.4
200 + 202 Non-Hodgkin's lymphoma 3 0.66 4.5 0.94–13.3
  1. Age 0–79 years; n = 180; 6885.2 person-years; 1958–2000.