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Figure 1 | Breast Cancer Research

Figure 1

From: Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status

Figure 1

Immunohistochemical detection of osteopontin (OPN), thrombospondin-1 (TSP-1) and tyrosinase-related protein-1 (TYRP-1) in normal and breast tumor cells. (A) Negative control (100×), (B) cytoplasmic OPN staining of the majority of tumor cells in selected cases (the stroma fibroblasts and endothelial cells did not stain for OPN) (200×), (C) TYRP-1 staining in normal breast duct epithelium (staining is specific for the epithelium and not for the surrounding stroma tissue) (100×), (D) TSP-1 stained only selected tumor cells (brown signal) and not the majority of the tumor (100×), (E) OPN was localized in normal breast duct epithelium but not in myoepithelial cells (100×), and (F) TRYP-1 in breast tumor cells (200×).

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