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Table 2 Parous women: multivariate analysis of the effects of risk factors for BRCA2-positive cases and BRCA2-negative cases separately

From: BRCA2mutation carriers, reproductive factors and breast cancer risk

  BRCA2-positive cases (n = 100) versus matched controls (n = 1000) BRCA2-negative cases (n versus = 361) matched controls (n = 1000)
Risk factor Odds ratio (95% confidence interval) P value Odds ratio (95% confidence interval) P value
Age at menarche 0.92 (0.74–1.14) 0.430 0.87 (0.77–0.99) 0.030
Age at first birth 1.01 (0.93–1.10) 0.738 1.02 (0.97–1.07) 0.352
Number of births 1.17 (0.95–1.43)* 0.132 0.87 (0.75–1.00)* 0.057
Total duration of breast-feeding (unit, 6 months) 0.96 (0.91–1.01)** 0.141 1.01 (0.98–1.03)** 0.579
  1. Odds ratios are presented per unit increment of the variables. * P = 0.007, odds ratio = 1.49 for the interaction between the number of births and the mutation status. ** P = 0.045, odds ratio = 0.93 for the interaction between the total duration of breast feeding and the mutation status. When testing for interaction between the other variables and the mutation status, P > 0.4.
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