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Table 2 Multiple logistic regression models for the validation and Silber and colleagues [1] studies

From: First-cycle absolute neutrophil count can be used to improve chemotherapy-dose delivery and reduce the risk of febrile neutropenia in patients receiving adjuvant therapy: a validation study

  MDACC study Silber model
Variable Odds ratio 95% CI P Odds ratio 95% CI P
Radiotherapy + chemotherapy indicatora -    9.5 2.5–36.6 0.0011
Cycle 1 nadir ANC (× 109/liter) 4.8 2.3–9.9 <0.0001 4.4 2.1–9.2 <0.0001
Cycle 1 hemoglobin decrease (g/dl) 1.8 1.0–3.3 0.0686 1.8 1.2–2.8 0.0074
n 143    95   
Model χ2 21.2 (2 df)    30.3 (3 df)   
Log-likelihood P <0.0001    <0.0001   
C-statistic 0.78    0.83   
Hosmer–Lemeshow lack-of-fit P 0.1268    0.6140   
  1. CI, confidence interval; df, degrees of freedom. aNot applicable to MDACC study because patients were not treated with concurrent radiotherapy.