Figure 1

Comparison of the rates of penetrance, of maintenance after oncogene downregulation, and of recurrence after oncogene downregulation in three conditional transgenic mouse models of mammary carcinogenesis. In the Wnt1 group, the first bars depict the rates for p53 wildtype (p53+/+) mice and the final two bars for p53 heterozygote (p53+/-) mice. The rate of oncogene-independent explant maintenance for primary tumor and metastasis in Wnt1 transgenic mice was 0%. 1°, primary tumor; Met, metastasis. Adapted from [15, 19, 21].