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Table 1 Known or suspected breast cancer genes

From: How many more breast cancer predisposition genes are there?

    Cumulative risk by age Contribution to
Gene Location Allele frequency* 50 years (%) 70 years (%) Breast cancer (%) Familial risk (%)
BRCA1 17q 0.0005-0.002 50 70 1-2 8
BRCA2 13q 0.0005-0.002 30 70 1-2 8
TP53 17p 0.0001 ~50   <1 <1
PTEN 10q <0.0001 ~30?   <<1 <1
ATM 11q 0.003 6 18 2 2
HRAS1 11q 0.06 3 10 9 4
  1. *Plausible estimate for large outbred populations.In the absence of other causes of death; these figures areintended as a guide only. Some studies suggest lower risks for BRCA1 and BRCA2