Table 4 Relative risk for breast cancer associated with the AR-CAG repeat

Rebbeck, 1999 [63]

Multi-institutional study of BRCA1 mutation carriers ascertained through families with a history of breast and/or ovarian cancer between 1978 and 1997

SS

28+ repeats

SL+LL

Spurdle, 1999 [64]

Early onset breast cancer (<40 years) and age matched controls from Australia

SS

21+ repeats

Age, country of birth, state, education, marital status, number of live births, height, weight1 year ago, age at menarche, oral contraceptive use, family history, estrogen receptor polymorphism, mother's country of birth, father's country of birth

SL

LL

Dunning, 1999 [65]

Cases from East Anglian region of the UK and random controls from the EPIC cohort

SS

23+ repeats

SL

LL

Giguere, 2001 [66]

Incident cases from Quebec city and age and area of residency matched controls

SS³

21+ repeats

Matched analysis

SL+LL

Kadouri, 2001 [67]

Affected and unaffected BRCA1/2 carriers from two genetics clinics: one in Jerusalem, Israel, and the other in London, UK

SS

28+ repeats

SL+LL

Haiman, 2002 [68]

Cases and controls from the Nurses' Health Study and controls matched on year of birth, menopausal status, postmenopausal hormone use, and time of day, month, and fasting status at blood draw

SS

22+ repeats

Age at menarche, parity, age at first birth, BMI at age 18 years, weight gain since age 8, benign breast disease, first degree family history, duration of postmenopausal hormone use; matched analysis

SL+LL

Suter, 2003 [69]

Cases (<45 years) identified through the Cancer Surveillance System of Western Washington and frequency-matched controls on 5-year age group and reference year

SS

22+ repeats

Age at reference and reference year

SL

LL