Figure 1From: Inflammatory breast cancer: Vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft modelMorphological and chromosomal analysis. (A) Histological features of the human original tumor revealed invasive ductal carcinoma and blood pooling without a lining of endothelia. (B) Characteristic appearance of the tumor at the site of subcutaneous inoculation. (C,D) Microscopic analysis of WIBC-9 stained with hematoxylin–eosin (C) and Giemsa (D) revealed hypervascularity, blood pooling without a lining of EC and no central necrosis or fibrosis in the center of the tumor nest. (E) Transmission electron microscopy revealed the interface between tumor cells and erythrocytes. (F) Phase-contrast electron microscopy clearly visualized erythrocytes between tumor cells. Erythrocytes appeared black. (G,H) Vasculogenic mimicry surrounding tumor cells was positive for Flt-1 (G) and Tie-2 (H). (I) Karyotype analysis of WIBC-9 revealing aneuploidy and marked chromosomal abnormalities.Back to article page