|
Cell type
|
Activity
|
Molecule
|
Reference
|
|---|
|
Macrophages
|
Proangiogenic
|
VEGF
|
[62]
|
| | |
TGF-α
|
[63, 64]
|
| | |
IL-8
|
[65]
|
| | |
bFGF
|
[66]
|
| | |
TP
|
[30, 67]
|
| | |
PDGF
|
[68]
|
| | |
Substance P
|
[69]
|
| | |
Prostaglandins
|
[70]
|
| |
Antiangiogenic
|
TSP-1
|
[71]
|
| | |
IFN-α
|
[72]
|
| | |
IFN-γ
|
[73]
|
| |
Protease
|
t-PA
|
[74]
|
| | |
u-PA
|
[75, 76]
|
| | |
MMP-1, -2, -3, -7, -9 and -12
|
[10, 12, 51]
|
|
Mast cells
|
Proangiogenic
|
VEGF
|
[77, 78]
|
| | |
bFGF
|
[79]
|
| | |
TGF-β
|
[80]
|
| | |
TNF-α
|
[81]
|
| | |
IL-8
|
[81]
|
| | |
Histamine
|
[48]
|
| |
Protease
|
Chymase
|
[9, 81, 82]
|
| | |
Tryptase
|
[9, 81]
|
| | |
MMP-9
|
[12]
|
| | |
Heparanase
|
[83]
|
|
Neutrophils
|
Proangiogenic
|
VEGF
|
[84]
|
| | |
IL-8
|
[84]
|
| |
Antiangiogenic
|
IL-12
|
[84]
|
| | |
IP-10
|
[85]
|
| | |
MIG
|
[85]
|
| |
Protease
|
MMP-9
|
[86]
|
| | |
u-PA
|
[86]
|
| | |
Elastase
|
[12, 87]
|
- bFGF, basic fibroblast growth factor; IFN, interferon; IP, interferon gamma inducible protein; MMP, matrix metalloprotease; PDGF, platelet-derived growth factor; TGF, transforming growth factor; TNF, tumour necrosis factor; TP, thymidine phosphorylase; t-PA, tissue-type plasminogen activator; u-PA, urokinase-type plasminogen activator; VEGF, vascular endothelial growth factor.
