Table 3 Relationships between breast cancer and putative risk factors by CYP17 genotype: Western New York Breast Cancer Study
From: CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors
All data | A1/A1 | A1/A2 and A2/A2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Case (n [%]) | Control (n [%]) | Odds ratio (95% CI)a | Case (n [%]) | Control (n [%]) | Odds ratio (95% CI)a | Case (n [%]) | Control (n [%]) | Odds ratio (95% CI)a | |
Premenopausal | |||||||||
Age at menarche | |||||||||
< 13 years | 47 (50) | 33 (39) | 1.00 | 30 (52) | 15 (31) | 1.00 | 17 (46) | 18 (49) | 1.00 |
≥ 13 years | 48 (51) | 52 (61) | 0.55 (0.27–1.10) | 28 (48) | 33 (69) | 0.37 (0.14–0.99) | 20 (54) | 19 (51) | 0.84 (0.27–2.61) |
Age at first birth | |||||||||
< 25 years | 55 (57) | 66 (77) | 1.00 | 34 (59) | 38 (79) | 1.00 | 21 (55) | 28 (74) | 1.00 |
≥ 25 years | 41 (43) | 20 (23) | 2.69 (1.34–5.39) | 24 (41) | 10 (21) | 4.30 (1.46–12.67) | 17 (45) | 10 (26) | 2.13 (0.76–6.02) |
Difficulty getting pregnant | |||||||||
No | 82 (79) | 79 (81) | 1.00 | 40 (71) | 38 (79) | 1.00 | 33 (89) | 29 (76) | 1.00 |
Yes | 22 (21) | 19 (19) | 0.97 (0.44–2.14) | 16 (29) | 10 (21) | 2.23 (0.69–7.24) | 4 (11) | 9 (24) | 0.38 (0.10–1.52) |
Ever use oral contraceptives | |||||||||
No | 44 (46) | 45 (52) | 1.00 | 24 (41) | 26 (54) | 1.00 | 20 (53) | 19 (50) | 1.00 |
Yes | 52 (54) | 41 (48) | 1.77 (0.84–3.74) | 34 (59) | 22 (46) | 3.24 (1.08–9.73) | 18 (47) | 19 (50) | 0.67 (0.20–2.26) |
Postmenopausal | |||||||||
Age at menarche | |||||||||
< 13 years | 56 (50) | 43 (42) | 1.00 | 25 (48) | 18 (38) | 1.00 | 31 (52) | 25 (46) 1.00 | |
≥ 13 years | 56 (50) | 59 (58) | 0.78 (0.42–1.48) | 27 (52) | 29 (62) | 0.72 (0.27–1.91) | 29 (48) | 30 (55) | 0.80 (0.33–1.93) |
Age at first birth | |||||||||
< 25 years | 60 (54) | 61 (60) | 1.00 | 29 (57) | 21 (48) | 1.00 | 31 (52) | 40 (73) | 1.00 |
≥ 25 years | 51 (46) | 41 (40) | 1.52 (0.83–2.77) | 22 (43) | 26 (55) | 0.68 (0.27–1.68) | 29 (48) | 15 (27) | 2.90 (1.30–6.97) |
Difficulty getting pregnant | |||||||||
No | 82 (79) | 79 (81) | 1.00 | 42 (86) | 32 (74) | 1.00 | 40 (73) | 47 (85) | 1.00 |
Yes | 22 (21) | 19 (19) | 1.19 (0.58–2.41) | 7 (14) | 11 (26) | 0.47 (0.14–1.50) | 15 (27) | 8 (15) | 2.59 (0.91–7.38) |
Ever use hormone replacement therapy | |||||||||
No | 89 (80) | 71 (70) | 1.00 | 40 (77) | 32 (68) | 1.00 | 49 (82) | 39 (71) | 1.00 |
Yes | 23 (20) | 31 (30) | 0.94 (0.31–2.78) | 12 (23) | 15 (32) | 0.80 (0.14–4.52) | 11 (18) | 16 (29) | 0.98 (0.23–4.26) |
Age at menopause | |||||||||
< 48 years | 58 (47) | 58 (57) | 1.00 | 24 (47) | 29 (62) | 1.00 | 29 (48) | 29 (53) | 1.00 |
≥ 48 years | 58 (52) | 44 (43) | 1.60 (0.91–2.84) | 27 (53) | 18 (38) | 1.98 (0.84–4.68) | 31 (52) | 26 (47) | 1.36 (0.61–3.06) |