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Table 5 Multivariate analysis of locoregional recurrence including the variables lymph node status, tumour size, oestrogen receptor (ER) status, Akt, treatment, and the interaction term Akt × radiotherapy

From: Akt kinases in breast cancer and the results of adjuvant therapy

  Number of patients Rate ratio Test for significance (P)
Number of positive nodesa
   0 32 1.0  
   1–3 149 16.8 0.000008
   > 3 84 31.1  
Tumour size (mm)a
   ≤ 20 111 1.0  
   21–30 78 2.6 0.00031
   > 30 76 5.7  
ER statusb
   ER- 78 1.0  
   ER+ 187 0.56 0.060
Aktb
   Akt- 155 1.0  
   Akt+ 110 0.71 0.33
Tamoxifenb
   No tamoxifen 132 1.0  
   Tamoxifen 133 0.65 0.17
Radiotherapy/chemotherapyb
   CMF chemotherapy 152 1.0   
   Radiotherapy 113 0.22 0.0065
Akt × radiotherapy
   0 221 1.0  
   1 44 4.3 0.042
  1. CMF, cyclophosphamide–methotrexate–5-fluorouracil. a The variable was coded 0, 1, 2. b The variable was coded 0, 1.