Akt kinases in breast cancer and the results of adjuvant therapy

Breast Cancer Research

Table 5 Multivariate analysis of locoregional recurrence including the variables lymph node status, tumour size, oestrogen receptor (ER) status, Akt, treatment, and the interaction term Akt × radiotherapy

	Number of patients	Rate ratio	Test for significance (P)
Number of positive nodes^a
0	32	1.0
1–3	149	16.8	0.000008
> 3	84	31.1
Tumour size (mm)^a
≤ 20	111	1.0
21–30	78	2.6	0.00031
> 30	76	5.7
ER status^b
ER-	78	1.0
ER+	187	0.56	0.060
Akt^b
Akt-	155	1.0
Akt+	110	0.71	0.33
Tamoxifen^b
No tamoxifen	132	1.0
Tamoxifen	133	0.65	0.17
Radiotherapy/chemotherapy^b
CMF chemotherapy 152	1.0
Radiotherapy	113	0.22	0.0065
Akt × radiotherapy
0	221	1.0
1	44	4.3	0.042

CMF, cyclophosphamide–methotrexate–5-fluorouracil. ^a The variable was coded 0, 1, 2. ^b The variable was coded 0, 1.

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