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Table 4 Multivariate analysis of distant recurrence in oestrogen receptor-positive patients including the variables lymph node status, tumour size, Akt, treatment, and the interaction term Akt × tamoxifen

From: Akt kinases in breast cancer and the results of adjuvant therapy

 

Number of patients

Rate ratio

Test for significance (P)

Number of positive nodesa

   0

19

1.0

 

   1–3

119

4.3

0.000078

   > 3

58

7.4

 

Tumour size (mm)a

   ≤ 20

89

1.0

 

   21–30

62

1.5

0.0031

   > 30

45

2.7

 

Aktb

   Akt-

107

1.0

 

   Akt+

78

0.53

0.038

Radiotherapy/chemotherapyb

   Radiotherapy

86

1.0

 

   CMF chemotherapy

110

0.91

0.65

Tamoxifenb

   No tamoxifen

100

1.0

 

   Tamoxifen

96

0.40

0.0010

Akt × tamoxifen

   0

147

1.0

 

   1

38

1.7

0.28

  1. CMF, cyclophosphamide–methotrexate–5-fluorouracil. a The variable was coded 0, 1, 2. b The variable was coded 0, 1.