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Table 4 Multivariate analysis of distant recurrence in oestrogen receptor-positive patients including the variables lymph node status, tumour size, Akt, treatment, and the interaction term Akt × tamoxifen

From: Akt kinases in breast cancer and the results of adjuvant therapy

  Number of patients Rate ratio Test for significance (P)
Number of positive nodesa
   0 19 1.0  
   1–3 119 4.3 0.000078
   > 3 58 7.4  
Tumour size (mm)a
   ≤ 20 89 1.0  
   21–30 62 1.5 0.0031
   > 30 45 2.7  
Aktb
   Akt- 107 1.0  
   Akt+ 78 0.53 0.038
Radiotherapy/chemotherapyb
   Radiotherapy 86 1.0  
   CMF chemotherapy 110 0.91 0.65
Tamoxifenb
   No tamoxifen 100 1.0  
   Tamoxifen 96 0.40 0.0010
Akt × tamoxifen
   0 147 1.0  
   1 38 1.7 0.28
  1. CMF, cyclophosphamide–methotrexate–5-fluorouracil. a The variable was coded 0, 1, 2. b The variable was coded 0, 1.