The sequence of the promoter region between the NBR2 and the BRCA1 genes is indicated. The transcriptional start sites are indicated by the left and right pointing arrows for the respective genes. Binding sites for transcription factors identified as being important for promoter activity are boxed. The minimal bidirectional promoter  is indicated by the dashed line. The first exon of the BRCA1 gene is indicated by the shaded box. CpG dinucleotides that are potentially methylated are shown in red. The location of an EcoRI and Sac I are indicated by thick lines.