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Figure 2 | Breast Cancer Research

Figure 2

From: Inhibition of E2-induced expression of BRCA1 by persistent organochlorines

Figure 2

Effect of persistent organochlorines on BRCA1 mRNA expression in (a) MCF-7 and (b) MDA-MB-231. All values are normalized to the internal control (GADPH) and then related to the solvent control (set to 1). Dark bars indicate cotreatment of 17β-estradiol and the given compound. * P < 0.05 compared with solvent-treated cells, ** P < 0.05 compared with 17β-estradiol (10 nM)-exposed cells. Data are presented as mean ± standard deviation of at least three independent experiments. E2, 17β-estradiol; Tox.Tech., toxaphene (technical mixture); TCDD, 2,3,7,8 tetrachlorodibenzo-p-dioxin; PCB, polychlorinated biphenyl; EtOH, ethanol; DMSO, dimethyl sulfoxide.

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