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Figure 2 | Breast Cancer Research

Figure 2

From: Progesterone receptors - animal models and cell signaling in breast cancer: Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics

Figure 2

Paracrine mode of action for progesterone-induced branching morphogenesis in the mammary gland. (a) Indirect immunofluorescence analysis of a rat mammary gland shows luminal epithelial cells expressing the progesterone receptor (PR) (red) or undergoing proliferation (green) as measured by 5-bromo-deoxyuridine. The arrow indicates a single proliferating cell (yellow), which also expresses the PR. Scale bar represents 50 m. (b) All nuclei in the field shown in (a), as detected by 6-diamidino-2-phenylindole incorporation. Details of this experiment are described elsewhere [5]. (c) The conceptual idea of a paracrine mode of action for progesterone in mammary branching morphogenesis. 'X' denotes the elusive downstream paracrine mediator(s) of the progesterone (P4) proliferative signal. Adapted from Lydon et al. [5].

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Breast Cancer Research

ISSN: 1465-542X

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