Table 3 Crude odds ratios and 95% confidence intervals for V89L polymorphism by subgroup
Genotype | ||||
|---|---|---|---|---|
Subgroup | V/V | V/L | L/L | V/L + L/L |
Age at diagnosis | ||||
< 45 years | 1.00 | 0.71 (0.25–1.99) | 0.45 (0.14–1.52) | 0.62 (0.23–1.64) |
≥ 45 years | 1.00 | 1.28 (0.74–2.21) | 0.70 (0.37–1.22) | 1.00 (0.61–1.67) |
Body mass index | ||||
< 22 kg/m2 | 1.00 | 1.06 (0.55–2.06) | 0.48 (0.23–1.00) | 0.80 (0.43–1.48) |
≥ 22 kg/m2 | 1.00 | 1.19 (0.59–2.38) | 0.82 (0.37–1.79) | 1.04 (0.54–1.99) |
Age at menarche | ||||
< 14 years | 1.00 | 1.36 (0.67–2.75) | 0.76 (0.35–1.66) | 1.10 (0.56–2.13) |
≥ 14 years | 1.00 | 0.97 (0.50–1.88) | 0.51 (0.24–1.09) | 0.78 (0.42–1.43) |
Age at first birth | ||||
< 25 years | 1.00 | 1.08 (0.49–2.38) | 0.60 (0.25–1.44) | 0.87 (0.42–1.82) |
≥ 25 years | 1.00 | 1.24 (0.64–2.42) | 0.67 (0.31–1.42) | 0.99 (0.53–1.85) |
No birth | 1.00 | 0.78 (0.18–3.36) | 0.43 (0.08–2.17) | 0.63 (0.16–2.46) |
Number of births | ||||
< 2 | 1.00 | 0.81 (0.27–2.38) | 0.40 (0.12–1.32) | 0.63 (0.23–1.74) |
≥ 2 | 1.00 | 1.22 (0.71–2.08) | 0.68 (0.37–1.25) | 0.99 (0.60–1.63) |
Menopause state | ||||
Premenopause | 1.00 | 1.01 (0.49–2.09) | 0.67 (0.29–1.52) | 0.88 (0.45–1.74) |
Postmenopause | 1.00 | 1.16 (0.60–2.23) | 0.56 (0.27–1.18) | 0.88 (0.48–1.62) |
Alcohol | ||||
< 1 day/week | 1.00 | 1.19 (0.69–2.05) | 0.66 (0.36–1.22) | 0.97 (0.58–1.60) |
≥ 1 day/week | 1.00 | 0.94 (0.33–2.65) | 0.48 (0.15–1.50) | 0.72 (0.28–1.88) |
Smoking | ||||
Noncurrent | 1.00 | 1.29 (0.78–2.13) | 0.64 (0.36–1.12) | 1.00 (0.63–1.59) |
Current | 1.00 | 0.16 (0.02–1.51) | 0.20 (0.02–2.18) | 0.17 (0.02–1.55) |
Family history of breast cancer | ||||
No | 1.00 | 1.22 (0.73–2.03) | 0.59 (0.33–1.05) | 0.95 (0.59–1.52) |
Yes | 1.00 | 0.73 (0.15–3.50) | 1.09 (0.19–6.20) | 0.86 (0.21–3.54) |