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Table 3 Crude odds ratios and 95% confidence intervals for V89L polymorphism by subgroup

From: A49T, V89L and TA repeat polymorphisms of steroid 5α-reductase type II and breast cancer risk in Japanese women

  Genotype
Subgroup V/V V/L L/L V/L + L/L
Age at diagnosis     
   < 45 years 1.00 0.71 (0.25–1.99) 0.45 (0.14–1.52) 0.62 (0.23–1.64)
   ≥ 45 years 1.00 1.28 (0.74–2.21) 0.70 (0.37–1.22) 1.00 (0.61–1.67)
Body mass index     
   < 22 kg/m2 1.00 1.06 (0.55–2.06) 0.48 (0.23–1.00) 0.80 (0.43–1.48)
   ≥ 22 kg/m2 1.00 1.19 (0.59–2.38) 0.82 (0.37–1.79) 1.04 (0.54–1.99)
Age at menarche     
   < 14 years 1.00 1.36 (0.67–2.75) 0.76 (0.35–1.66) 1.10 (0.56–2.13)
   ≥ 14 years 1.00 0.97 (0.50–1.88) 0.51 (0.24–1.09) 0.78 (0.42–1.43)
Age at first birth     
   < 25 years 1.00 1.08 (0.49–2.38) 0.60 (0.25–1.44) 0.87 (0.42–1.82)
   ≥ 25 years 1.00 1.24 (0.64–2.42) 0.67 (0.31–1.42) 0.99 (0.53–1.85)
   No birth 1.00 0.78 (0.18–3.36) 0.43 (0.08–2.17) 0.63 (0.16–2.46)
Number of births     
   < 2 1.00 0.81 (0.27–2.38) 0.40 (0.12–1.32) 0.63 (0.23–1.74)
   ≥ 2 1.00 1.22 (0.71–2.08) 0.68 (0.37–1.25) 0.99 (0.60–1.63)
Menopause state     
   Premenopause 1.00 1.01 (0.49–2.09) 0.67 (0.29–1.52) 0.88 (0.45–1.74)
   Postmenopause 1.00 1.16 (0.60–2.23) 0.56 (0.27–1.18) 0.88 (0.48–1.62)
Alcohol     
   < 1 day/week 1.00 1.19 (0.69–2.05) 0.66 (0.36–1.22) 0.97 (0.58–1.60)
   ≥ 1 day/week 1.00 0.94 (0.33–2.65) 0.48 (0.15–1.50) 0.72 (0.28–1.88)
Smoking     
   Noncurrent 1.00 1.29 (0.78–2.13) 0.64 (0.36–1.12) 1.00 (0.63–1.59)
   Current 1.00 0.16 (0.02–1.51) 0.20 (0.02–2.18) 0.17 (0.02–1.55)
Family history of breast cancer     
   No 1.00 1.22 (0.73–2.03) 0.59 (0.33–1.05) 0.95 (0.59–1.52)
   Yes 1.00 0.73 (0.15–3.50) 1.09 (0.19–6.20) 0.86 (0.21–3.54)