Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?

Breast Cancer Research

Table 1 Genetic alterations of the Trp53 gene in mice

Modification	Promoter	Pregnancy required	Effect	References
p53 deficient, Trp53 ^-	-	No	No p53 protein	[15–17]
Mutant p53 transgenes
p53-R172H	WAP	Yes	Dominant negative/gain of function	[33, 40]
p53-R172L	WAP	Yes	Super active p53	[49, 50]

ISSN: 1465-542X